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- Title
Maternal high-fat diet and obesity impact palatable food intake and dopamine signaling in nonhuman primate offspring.
- Authors
Rivera, Heidi M.; Kievit, Paul; Kirigiti, Melissa A.; Bauman, Leigh Ann; Baquero, Karalee; Blundell, Peter; Dean, Tyler A.; Valleau, Jeanette C.; Takahashi, Diana L.; Frazee, Tim; Douville, Luke; Majer, Jordan; Smith, M. Susan; Grove, Kevin L.; Sullivan, Elinor L.
- Abstract
<bold>Objective: </bold>To utilize a nonhuman primate model to examine the impact of maternal high-fat diet (HFD) consumption and pre-pregnancy obesity on offspring intake of palatable food and to examine whether maternal HFD consumption impaired development of the dopamine system, critical for the regulation of hedonic feeding.<bold>Methods: </bold>The impact of exposure to maternal HFD and obesity on offspring consumption of diets of varying composition was assessed after weaning. The influence of maternal HFD consumption on the development of the prefrontal cortex-dopaminergic system at 13 months of age was also examined.<bold>Results: </bold>During a preference test, offspring exposed to maternal HFD consumption and obesity displayed increased intake of food high in fat and sugar content relative to offspring from lean control mothers. Maternal HFD consumption suppressed offspring dopamine signaling (as assessed by immunohistochemistry) relative to control offspring. Specifically, there was decreased abundance of dopamine fibers and of dopamine receptor 1 and 2 proteins.<bold>Conclusions: </bold>This study reveals that offspring exposed to both maternal HFD consumption and maternal obesity during early development are at increased risk for obesity due to overconsumption of palatable energy-dense food, a behavior that may be related to reduced central dopamine signaling.
- Subjects
HIGH-fat diet; OBESITY; DOPAMINE; PRIMATES; ANIMAL young; PREFRONTAL cortex; CONTROL groups; IMMUNOHISTOCHEMISTRY; ANIMAL experimentation; BIOLOGICAL models; CELLULAR signal transduction; DIET; FOOD habits; INGESTION; MOTHERS; NUTRITIONAL requirements; PREGNANCY complications; RESEARCH funding; TASTE; PRENATAL exposure delayed effects
- Publication
Obesity (19307381), 2015, Vol 23, Issue 11, p2157
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.21306