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- Title
miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6.
- Authors
Franzoni, Eleonora; Booker, Sam A.; Parthasarathy, Srinivas; Rehfeld, Frederick; Grosser, Sabine; Srivatsa, Swathi; Fuchs, Heiko R.; Tarabykin, Victor; Vida, Imre; Wulczyn, F. Gregory
- Abstract
The article examines the regulation of neuronal migration, outgrowth, and intrinsic excitability by the brain-enriched microRNA miR-128. Topics discussed include the implication of miR-128 in the control of neurogenesis and synaptogenesis and the restriction of microRNA accumulation to post-mitotic neurons due to post-transcriptional mechanisms. Overmigration as a result of sponge-mediated inhibition and reduced complexity of dendritic arborization due to premature expression are mentioned.
- Subjects
NEURONS; MICRORNA; DEVELOPMENTAL neurobiology; BIOACCUMULATION; GENE expression
- Publication
eLife, 2015, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.04263.001