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- Title
Cross-Sectional, Primary Care-Based Study of the Prevalence of Hypoandrogenemia in Nondiabetic Young Men with Obesity.
- Authors
Molina‐Vega, María; Asenjo‐Plaza, Maite; García‐Ruiz, María Concepción; Varea‐Marineto, Enrique; Casal‐Nievas, Nieves; Álvarez‐Millán, Juan J.; Cabezas‐Sanchez, Pablo; Cardona‐Díaz, Fernando; Queipo‐Ortuño, María Isabel; Castellano‐Castillo, Daniel; Tinahones, Francisco J.; Fernández‐García, José C.; Molina-Vega, María; Asenjo-Plaza, Maite; García-Ruiz, María Concepción; Varea-Marineto, Enrique; Casal-Nievas, Nieves; Álvarez-Millán, Juan J; Cabezas-Sanchez, Pablo; Cardona-Díaz, Fernando
- Abstract
<bold>Objective: </bold>Obesity-associated hypoandrogenemia is increasing in parallel to the obesity epidemic. The prevalence of hypoandrogenemia in nondiabetic young men with obesity is not known. This study aimed to evaluate the prevalence of hypoandrogenemia and associated risk factors in this population.<bold>Methods: </bold>This cross-sectional study included 266 nondiabetic men < 50 years of age with obesity who were referred from primary care. Total testosterone (high-performance liquid chromatography mass spectrometry), sex hormone-binding globulin, free testosterone (FT), luteinizing hormone (LH), high-sensitivity C-reactive protein, and homeostatic model assessment of insulin resistance were determined. Body composition and erectile function were also assessed. Hypoandrogenemia was defined as FT level < 70 pg/mL.<bold>Results: </bold>Subnormal FT concentrations were found in 25.6% of participants. Hypoandrogenemia prevalence was different along the BMI continuum, being > 75% in individuals with BMI ≥ 50 kg/m2 . A multivariate regression analysis indicated that increasing BMI (P < 0.001), age (P = 0.049), and reduced LH levels (P = 0.003) were independent risk factors for hypoandrogenemia.<bold>Conclusions: </bold>In a primary care-based cohort of nondiabetic young men with obesity, hypoandrogenemia was a very prevalent finding and was directly associated with adiposity. Obesity, age, and reduced LH levels were independent risk factors associated with hypoandrogenemia. Further prospective studies are needed to evaluate the long-term consequences of hypoandrogenemia in this population.
- Subjects
HIGH performance liquid chromatography; YOUNG men; OBESITY; C-reactive protein; BODY composition; OBESITY complications; COMPARATIVE studies; GLYCOPROTEINS; HYPOGONADISM; IMPOTENCE; LONGITUDINAL method; LUTEINIZING hormone; RESEARCH methodology; MEDICAL cooperation; PRIMARY health care; RESEARCH; TESTOSTERONE; EVALUATION research; BODY mass index; DISEASE prevalence; CROSS-sectional method; DISEASE complications
- Publication
Obesity (19307381), 2019, Vol 27, Issue 10, p1584
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22579