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- Title
Metabolically Healthy Obesity and Risk for Atrial Fibrillation: The HUNT Study.
- Authors
Feng, Tingting; Vegard, Malmo; Strand, Linn B.; Laugsand, Lars E.; Mørkedal, Bjørn; Aune, Dagfinn; Vatten, Lars; Ellekjær, Hanne; Loennechen, Jan P.; Mukamal, Kenneth; Janszky, Imre; Ellekjaer, Hanne
- Abstract
<bold>Objective: </bold>Atrial fibrillation (AF) is the most common arrhythmia and has been described as a global epidemic. Although AF is associated with both obesity and its metabolic consequences, little is known about the association between metabolically healthy obesity and AF.<bold>Methods: </bold>In a population-based study, 47,870 adults were followed for incident AF from 2006 to 2008 until 2015. Participants were classified according to BMI and metabolic status (using waist circumference, triglycerides, high-density lipoprotein cholesterol, blood pressure, and glucose) at baseline.<bold>Results: </bold>During a median follow-up of 8.1 years, 1,758 participants developed AF. Compared with metabolically healthy individuals with BMI < 25 kg/m2 , the multivariable-adjusted hazard ratios for metabolically healthy and unhealthy obesity were 1.6 (95% CI: 1.2 to 2.1) and 1.6 (95% CI: 1.3 to 1.9), respectively. AF risk increased according to the severity of obesity.<bold>Conclusions: </bold>Metabolically healthy and unhealthy obesity increased AF risk to a similar extent. Severity of obesity was positively associated with AF risk regardless of metabolic status.
- Subjects
OBESITY; TYPE 2 diabetes; HYPERTENSION; BODY mass index; PHYSICAL activity
- Publication
Obesity (19307381), 2019, Vol 27, Issue 2, p332
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22377