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- Title
MiR-27b-3p Regulation in Browning of Human Visceral Adipose Related to Central Obesity.
- Authors
Yu, Jing; Lv, Yifan; Di, Wenjuan; Liu, Juan; Kong, Xiaocen; Sheng, Yunlu; Huang, Min; Lv, Shan; Qi, Hanmei; Gao, Mei; Liang, Hui; Kim, Sarah; Fu, Zan; Zhou, Hong; Ding, Guoxian
- Abstract
<bold>Objective: </bold>Given the rising prevalence of central obesity and the discovery that beige cells appear within white adipose tissue, strategies to enhance these energy-expending adipocytes or "browning" within white adipose depots have become of therapeutic interest to combat obesity and its associated disorders. This study focused on, the role of microRNA (miRNA)-27b-3p in human visceral adipose tissue (VAT) browning.<bold>Methods: </bold>Expression of miR-27b-3p and UCP1 in VAT and serum of humans was measured. MiR-27b-3p was overexpressed or suppressed in human visceral stromal fraction cells to analyze the potential role of miR-27b-3p.<bold>Results: </bold>UCP1 expression in human VAT decreased with elevated BMI and waist-hip ratio, whereas expression of miR-27b-3p was found to correlate positively with BMI and waist-hip ratio. High expression of miR-27b-3p was associated with reduced browning ability of human visceral adipocytes. Antagonism of miR-27b-3p led to the enhancement of browning ability in human visceral adipocytes.<bold>Conclusions: </bold>These findings highlight the decreased browning ability of VAT from humans with obesity and the role of miR-27b-3p in regulating browning of human visceral adipocytes. They suggest that miR-27b-3p should be further explored as a potential target for the treatment of central obesity.
- Subjects
OBESITY treatment; VISCERA abnormalities; ADIPOSE tissues; GENE expression; FAT cells; RNA metabolism; COMPARATIVE studies; GENETIC techniques; RESEARCH methodology; MEDICAL cooperation; OBESITY; RESEARCH; RNA; EVALUATION research
- Publication
Obesity (19307381), 2018, Vol 26, Issue 2, p387
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22104