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- Title
Cluster of differentiation 19 chimeric antigen receptor T-cell therapy in pediatric acute lymphoblastic leukemia.
- Authors
Fu, Zexin; Zhou, Jinlei; Chen, Rui; Jin, Yihua; Ni, Ting; Qian, Lingbo; Xiao, Chi
- Abstract
Chimeric antigen receptor (CAR) T cells have an unprecedented positive curative effect for hematological malignances. Most notably, cluster of differentiation 19 (CD19) CAR T-cell therapy for pediatric acute lymphoblastic leukemia is associated with a high complete remission rate and has aroused considerable attention in the medical field. However, it also causes a series of adverse reactions and increases the risk of recurrence. The present review examines the results of CD19 CAR T-cell therapy and lists its adverse effects. In addition, some of the mechanisms of recurrence are characterized and applicable strategies to address this challenging problem are proposed.
- Subjects
CHIMERIC antigen receptors; PEDIATRIC therapy; LYMPHOBLASTIC leukemia; ACUTE leukemia; T cells
- Publication
Oncology Letters, 2020, Vol 20, Issue 4, pN.PAG
- ISSN
1792-1074
- Publication type
Article