We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation.
- Authors
Hwang, Jin Taek; Kim, Sanghee; Yoon, Bo-ra; Choi, Inwook; Choi, Sang Yoon
- Abstract
The potent suppression of adipocyte differentiation by 4-(4-methylbenzamino)benzoate was discovered during the search for new antiobesity compounds. 4-(4-methylbenzamino)benzoate was observed to suppress adipocyte differentiation in 3T3-L1 cells by 96.8% at 50 μM without cytotoxicity. In addition, 4-(4-methylbenzamino)benzoate reduced the cellular expression of fatty acid synthase in a concentration-dependent manner, as well as suppressing PPAR-gamma activity, which controls fatty acid storage and glucose metabolism. Based on these results, 4-(4-methylbenzamino)benzoate shows potential as an antiobesity material.
- Subjects
BENZOATES; CARBOCYCLIC acids; CARBOHYDRATE metabolism; OBESITY; FATTY acids
- Publication
Journal of Chemistry, 2015, Vol 2015, p1
- ISSN
2090-9063
- Publication type
Article
- DOI
10.1155/2015/171570