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- Title
Role of Yes-associated protein in cancer: An update.
- Authors
ABYLKASSOV, RAMAZAN; YINGQIU XIE
- Abstract
Yes-associated protein (YAP) is an oncoprotein located in the cytoplasm in an inactive form, and when activated, it translocates to the nucleus and activates the transcription of genes responsible for cell division and apoptosis. YAP is one of the downstream regulatory proteins in the Hippo signaling pathway, which is important in cell proliferation and regeneration. Due to its great importance, YAP is regulated very strictly by different regulatory systems. The present review will focus on the canonical pathways of YAP, and will provide details on the most recent findings regarding its regulation and role in tumorigenesis, specifically in prostate tumor progression.
- Subjects
CANCER; PROTEINS; CYTOPLASM; GENETIC transcription; CELL proliferation
- Publication
Oncology Letters, 2016, Vol 12, Issue 4, p2277
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.4955