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- Title
Identification of a circulating immunological signature predictive of response to immune checkpoint inhibitors in patients with advanced non‐small cell lung cancer.
- Authors
Khatir, Wassila; Humbert, Olivier; Benzaquen, Jonathan; Bontoux, Christophe; Neels, Jaap; Berland, Léa; Rivera, Fabian Andrés Gallardo; Allegra, Maryline; Salah, Myriam; Tanga, Virginie; Bordone, Olivier; Fayada, Julien; Lespinet‐Fabre, Virginie; Bohly, Doriane; Long‐Mira, Elodie; Lassalle, Sandra; Vouret, Valérie; Brest, Patrick; Mograbi, Baharia; Maniel, Charlotte
- Abstract
Dear Editor, This pilot study suggests the presence of two different profiles of patients with advanced non-small cell lung cancer (aNSCLC), responding to immune checkpoint inhibitors (ICIs). These results suggest a difference in T-cell activity in TruCulture (e.g. the "high concentrations" group with a high T-cell activity, and the "low concentrations" group with low T-cell activity). The correlation heat map is calculated in order to classify the patients and/or the analytes using a dendrogram gathering the patients/analytes having correlated profiles, the distance chosen being 1 - R, R being the correlation coefficient.
- Subjects
NON-small-cell lung carcinoma; IMMUNE checkpoint inhibitors; PROGRAMMED cell death 1 receptors; CYTOTOXIC T cells; IMMUNE response
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 8, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1018