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- Title
Key role of quorum‐sensing mutations in the development of Staphylococcus aureus clinical device‐associated infection.
- Authors
He, Lei; Zhang, Feiyang; Jian, Ying; Lv, Huiying; Hamushan, Musha; Liu, Junlan; Liu, Yao; Wang, Hua; Tang, Jin; Han, Pei; Burgin, Dylan J.; Dickey, Seth W.; Shen, Hao; Li, Min; Otto, Michael
- Abstract
Hemolysis (F) and biofilm formation (G) of T1, T2 and repaired T2 isolates is shown. n = 8/group. (B) Analysis of biofilm formation and biofilm antibiotic resistance by CLSM for Case 1 T1 versus T2 isolates and LAC versus LAC agr isogenic strains. In the present study, we show that the development of I Staphylococcus aureus i device-associated infection involves mutations in the quorum-sensing system Agr that increase biofilm formation and thereby bacterial resistance to antibiotics.
- Subjects
QUORUM sensing; STAPHYLOCOCCUS aureus; METHICILLIN-resistant staphylococcus aureus; STAPHYLOCOCCUS aureus infections; DRUG resistance in bacteria; GENETIC mutation
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 4, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.801