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- Title
Anti‐Monkeypox Infection Approaches: From Prevention to Therapeutic Lines.
- Authors
Ghafari, Somayeh; Rukerd, Mohammad Rezaei Zadeh; Bashash, Davood; Nakhaie, Mohsen; Charostad, Javad; Zarei, Mohammad; Dehghani, Azam
- Abstract
Vaccination for monkeypox prevention in persons with high-risk sexual behaviours to control on-going outbreak of monkeypox virus clade 3. It is important to consider patients as infectious from the beginning of the prodrome or rash until the scabs fall off.[[8]] The preferred diagnostic test for identifying a person with suspected active Mpox infection is to examine samples taken from a skin lesion using molecular tests such as polymerase chain reaction.[[8], [10]] To effectively treat Mpox, it is necessary to develop medications with specific viral targets.[6] Antiviral medications for Mpox treatment have not yet received official approval.[11] Considering the number of reported Mpox mortalities and the severity of Mpox in some patients, immunocompromised individuals, and pregnant women, the study of antiviral therapies should continue to be an option.[11] This review attempts to summarize the preventive approaches and current applicable treatment options against Mpox infection. Keywords: drug interactions; monkeypox; prevention; treatment; viral infection EN drug interactions monkeypox prevention treatment viral infection 659 666 8 07/04/23 20230701 NES 230701 Monkeypox (Mpox) virus was first observed in cynomolgus monkeys kept for research in Denmark in 1958,[1] and Mpox in humans was first determined in Central Africa in 1970 with clinical similarities and different epidemiology to smallpox.[2] Throughout history, the Mpox virus has caused several outbreaks, the most recent of which occurred in endemic and nonendemic regions around the world in 2022.[[3]] Mpox virus, with a double-stranded DNA genome, belongs to the Poxviridae family, the Chordopoxvirinae subfamily, and the genus I Orthopoxvirus i (OPXV).[5] Two genetically different Mpox viral strains (clades) have been discovered, one in Central Africa and the other in West Africa. Anti-Monkeypox Infection Approaches: From Prevention to Therapeutic Lines.
- Subjects
MEDICAL personnel; FEVER; BREASTFEEDING; PLANT viruses; VACCINIA; SMALLPOX; DRUG side effects; INFECTION
- Publication
Clinical Pharmacology in Drug Development, 2023, Vol 12, Issue 7, p659
- ISSN
2160-763X
- Publication type
Article
- DOI
10.1002/cpdd.1275