We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expression of Tie-1 and 2 receptors, and angiopoietin-1, 2 and 4 in gastric carcinoma; immunohistochemical analyses and correlation with clinicopathological factors.
- Authors
Nakayama, T.; Yoshizaki, A.; Kawahara, N.; Ohtsuru, A.; Wen, C. Y.; E. Fukuda, C. Y.; M. Nakashima; I. Sekine
- Abstract
Nakayama T, Yoshizaki A, Kawahara N, Ohtsuru A, Wen C Y, Fukuda E, Nakashima M & Sekine I (2004) Histopathology 44, 232–239 Expression of Tie-1 and 2 receptors, and angiopoietin-1, 2 and 4 in gastric carcinoma; immunohistochemical analyses and correlation with clinicopathological factors There is strong evidence that tyrosine kinases are involved in the regulation of tumour progression, cellular growth and differentiation. Recently, many kinds of tyrosine kinase receptors have been reported, and among them Tie-1 and 2 constitute a major class. Angiopoietin (Ang)-1 is known as a ligand of the Tie-2 tyrosine kinase receptor. The aim of this study was to determine the expression profile of Tie-1 and 2 and Ang-1, 2 and 4 in gastric adenocarcinoma. Eighty-nine cases of surgically resected human gastric adenocarcinoma were studied by immunohistochemistry. Of these, 60 (67.4%), 61 (68.5%), 69 (77.5%), 75 (84.3%), and 47 cases (52.8%) showed positive staining in the cytoplasm of carcinoma cells for the Tie-1 and 2 and Ang-1, 2 and 4 proteins, respectively. The expression of Ties and Angs was significantly correlated with several type of histological differentiation and several clinicopathological factors. Ties and Angs were highly expressed in human gastric adenocarcinoma cells. These findings suggest that the Tie–Ang receptor–ligand complex is one of the factors involved in the cellular differentiation and progression of human gastric adenocarcinoma.
- Subjects
GENE expression; REGULATION of cell growth; LIGAND binding (Biochemistry); ADENOCARCINOMA; CYTOPLASM; TYROSINE; TUMORS
- Publication
Histopathology, 2004, Vol 44, Issue 3, p232
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.0309-0167.2004.01817.x