We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Successful use of eculizumab in immediate ANCA vasculitis recurrence in a pediatric kidney transplant.
- Authors
Peterson, Caitlin G.; Jackson, Rachel L.
- Abstract
Background: Kidney transplantation is an acceptable therapy end‐stage kidney disease secondary to antineutrophil cytoplasmic antibody‐associated vasculitis with risk of disease recurrence ranging from 3% to 17%. Standard posttransplant immunosuppression is the mainstay of therapy after recurrence. Recently, new medications focused on complement regulation and avoidance of steroids have been shown to be effective in treating antineutrophil cytoplasmic antibody (ANCA) vasculitis with no studies in the pediatric population. Methods: We report a 5‐year‐old patient with immediate recurrence of positive myeloperoxidase (MPO)‐ANCA vasculitis after deceased donor kidney transplant and the novel use of eculizumab to salvage the graft. Results: Eculizumab and transition to ravulizumab has been successful in improving graft function and maintenance of disease remission after immediate MPO‐ANCA vasculitis recurrence posttransplant. Conclusions: Complement inhibitors may be used in addition to standard immunosuppression postkidney transplant in a pediatric patient with MPO‐ANCA vasculitis recurrence without higher rates of infections.
- Subjects
KIDNEY transplantation; ANTINEUTROPHIL cytoplasmic antibodies; VASCULITIS; COMPLEMENT inhibition; CHRONIC kidney failure
- Publication
Pediatric Transplantation, 2024, Vol 28, Issue 3, p1
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/petr.14760