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- Title
Abnormal Brain Structure Morphology in Early-Onset Schizophrenia.
- Authors
Jia Cai; Wei Wei; Liansheng Zhao; Mingli Li; Xiaojing Li; Sugai Liang; Wei Deng; Xiang Dong Du; Qiang Wang; Wan-jun Guo; Xiaohong Ma; Sham, Pak C.; Tao Li
- Abstract
With less exposure to environmental and medication influences, individuals with earlyonset schizophrenia (EOS) may provide valuable evidence to study the pathogenesis and phenotypic pattern of schizophrenia. T1-weighted magnetic resonance images were collected in 60 individuals with EOS and 40 healthy controls. Voxel-based morphometry and surface-based morphometry analyzes were performed. Gray matter volume, cortical thickness and cortical surface area were compared between the EOS and healthy controls and among schizophrenia subgroups (with or without family history of schizophrenia). Compared with healthy controls, the EOS group had reduced gray matter volume in the bilateral middle temporal gyrus and reduced cortical thickness in several brain regions. The sporadic early onset schizophrenia and the familial early onset schizophrenia showed different brain structure morphology. These findings suggest that abnormal brain structure morphology, especially in the temporal and frontal lobes, may be an important pathophysiological feature of EOS.
- Subjects
BRAIN anatomy; BRAIN cortical thickness; GRAY matter (Nerve tissue); TEMPORAL lobe; VOXEL-based morphometry
- Publication
Frontiers in Psychiatry, 2022, Vol 13, p1
- ISSN
1664-0640
- Publication type
Article
- DOI
10.3389/fpsyt.2022.925204