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- Title
Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice.
- Authors
Xiaoyan Wang; Villar, Van Anthony M.; Armando, Ines; Eisner, Gilbert M.; Felder, Robin A.; Jose, Pedro A.
- Abstract
Dopamine is important in the pathogenesis of hypertension because of abnormalities in receptor-mediated regulation of renal sodium transport. Dopamine receptors are classified into D1-like (D1, D5) and D2-like (D2, D3, D4) subtypes, all of which are expressed in the kidney. Mice deficient in specific dopamine receptors have been generated to provide holistic assessment on the varying physiological roles of each receptor subtype. This review examines recent studies on these mutant mouse models and evaluates the impact of individual dopamine receptor subtypes on blood pressure regulation.
- Subjects
HYPERTENSION; DOPAMINE receptors; DOPAMINE; REGULATION of blood pressure; NEUROTRANSMITTER receptors; LABORATORY mice
- Publication
Pediatric Nephrology, 2008, Vol 23, Issue 12, p2131
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-008-0901-3