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- Title
Report IgG class antibodies from psoriasis patients recognize the 60-KDa heat-shock protein of Streptococcus pyogenes.
- Authors
Cancino-Díaz, Mario E.; Ruiz-González, Veróonica; Ramírez-Reséndiz, Luis; Ortiz, Blanca; Domínguez-López, María Lilia; Paredes-Cabrera, Giovanna C.; Gladys León-Dorantes; Blancas-González, Fernando; Jiménez-Zamudio, Luis; Ethel García-Latorre
- Abstract
Background We have previously found that psoriatic patients have lgG autoantibodies that recognize lesions but not autologous normal skin. The reactivity of the autoantibodies can be adsorbed with streptococcal antigens. Methods lgG antibodies were determined by immunoblot and ELISA to streptococcal antigens and by ELISA to the recombinants HSP60Sp, HSP70Sp, HSP60Ec and HSP60Hu, in plaque (PP) and guttate (GP) psoriasis patients, in healthy subjects (HC) and in individuals with streptococcal throat infections and high ASO titers, but without history of dermatological disease (ISp), Results We found by immunoblot that the lgG response to 71-, 60-, and 14-kDa protein fractions of Streptococcus pyogenes is important in psoriasis. We also found by ELISA that the response to the rHSP60Sp in PP was higher than in all the other three groups studied (P < 0.05) with an odds ratio of 11.11 (CI95% of 4.33-28.49).The PP infected with S. pyogenes had higher titers of the antirHSP6OSp, high ASO, and high PASI. The PP patients did not significantly recognize the HSP6OEc or the HSP6OHu. The GP patients had a higher response to the rHSP60Sp than the healthy controls or ISP patients (P < 0.05) but showed no association with the disease. The response of the ISp patients to the HSP60Sp was similar to the healthy controls. The response to the rHSP70Sp was similar in the PP patients and the healthy controls. Conclusion Results suggest that a high response to the HSP60Sp could be associated with the chronic form of psoriasis.
- Subjects
PSORIASIS; AUTOANTIBODIES; STREPTOCOCCUS; ANTIGENS; DERMATOLOGY; SKIN diseases
- Publication
International Journal of Dermatology, 2004, Vol 43, Issue 5, p341
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/j.1365-4632.2004.01884.x