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- Title
Bioactive Alkaloids from the Mangrove-Derived Fungus Nigrospora oryzae SYSU-MS0024.
- Authors
Chen, Xiaokun; Chen, Senhua; Guo, Heng; Lu, Xin; Shen, Hongjie; Liu, Lan; Wang, Li; Chen, Bin; Zhang, Yi; Liu, Yayue
- Abstract
Chemical investigation of marine fungus Nigrospora oryzae SYSU-MS0024 cultured on solid-rice medium led to the isolation of three new alkaloids, including a pair of epimers, nigrosporines A (1) and B (2), and a pair of enantiomers, (+)-nigrosporine C (+)-3, and (−)-nigrosporine C (−)-3, together with eight known compounds (4–11). Their structures were elucidated based on extensive mass spectrometry (MS) and 1D/2D nuclear magnetic resonance (NMR) spectroscopic analyses and compared with data in the literature. The absolute configurations of compounds 1–3 were determined by a combination of electronic circular dichroism (ECD) calculations, Mosher's method, and X-ray single-crystal diffraction technique using Cu Kα radiation. In bioassays, compound 2 exhibited moderate inhibition on NO accumulation induced by lipopolysaccharide (LPS) on BV-2 cells in a dose-dependent manner at 20, 50, and 100 μmol/L and without cytotoxicity in a concentration of 100.0 μmol/L. Moreover, compound 2 also showed moderate acetylcholinesterase (AChE) inhibitory activities with IC50 values of 103.7 μmol/L. Compound 5 exhibited moderate antioxidant activity with EC50 values of 167.0 μmol/L.
- Subjects
ACETYLCHOLINESTERASE; NUCLEAR magnetic resonance; ALKALOIDS; MARINE fungi; CYTOTOXINS; CIRCULAR dichroism; COPPER
- Publication
Marine Drugs, 2024, Vol 22, Issue 5, p214
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md22050214