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- Title
New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.
- Authors
Hou, Bolin; Liu, Sushi; Huo, Ruiyun; Li, Yueqian; Ren, Jinwei; Wang, Wenzhao; Wei, Tao; Jiang, Xuejun; Yin, Wenbing; Liu, Hongwei; Liu, Ling; Li, Erwei
- Abstract
Two new diterpenoids, hypoxyterpoids A (1) and B (2), and four new isocoumarin derivatives, hypoxymarins A–D (4–7), together, with seven known metabolites (3 and 8–13) were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds 1, 2, 4, 5, and 7 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4′ in 6 and C-9 in 7 were determined by [Rh2(OCOCF3)4]-induced ECD spectra. Compound 1 showed moderate α-glucosidase inhibitory activities with IC50 values of 741.5 ± 2.83 μM. Compounds 6 and 11 exhibited DPPH scavenging activities with IC50 values of 15.36 ± 0.24 and 3.69 ± 0.07 μM, respectively.
- Subjects
DITERPENES; ISOCOUMARINS; NUCLEAR magnetic resonance; FUNGI; CIRCULAR dichroism; METABOLITES
- Publication
Marine Drugs, 2021, Vol 19, Issue 7, p362
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md19070362