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- Title
Sortase A-Inhibitory Metabolites from a Marine-Derived Fungus Aspergillus sp.
- Authors
Park, Sung Chul; Chung, Beomkoo; Lee, Jayho; Cho, Eunji; Hwang, Ji-Yeon; Oh, Dong-Chan; Shin, Jongheon; Oh, Ki-Bong
- Abstract
Seven alkaloidal compounds (2–8) and one polyketide (1) were isolated from a semisolid rice culture of the marine-derived fungus Aspergillus sp. F452. Structures of the isolated compounds were elucidated based on spectroscopic data and comparisons with previously reported data. The alkaloidal compounds (2–8) displayed weak to moderate inhibitory activities against Staphylococcus aureus-derived sortase A (SrtA) without affecting cell viability. Aspermytin A (1) strongly inhibited SrtA activity, with an IC50 value of 146.0 μM, and significantly reduced bacterial adherence to fibronectin-coated surfaces. The present results indicate that the underlying mechanism of action of compound 1 is associated with the inhibition of SrtA-mediated S. aureus adhesion to fibronectin, thus potentially serving as an SrtA inhibitor.
- Subjects
METABOLITES; FUNGI; CELL survival; STAPHYLOCOCCUS; ASPERGILLUS; ASPERGILLUS niger
- Publication
Marine Drugs, 2020, Vol 18, Issue 7, p359
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md18070359