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- Title
Boron Neutron Capture Therapy - A Literature Review.
- Authors
NEDUNCHEZHIAN, KAVITAA; ASWATH, NALINI; THIRUPPATHY, MANIGANDAN; THIRUGNANAMURTHY, SARUMATHI
- Abstract
Boron Neutron Capture Therapy (BNCT) is a radiation science which is emerging as a hopeful tool in treating cancer, by selectively concentrating boron compounds in tumour cells and then subjecting the tumour cells to epithermal neutron beam radiation. BNCT bestows upon the nuclear reaction that occurs when Boron-10, a stable isotope, is irradiated with low-energy thermal neutrons to yield a particles (Helium-4) and recoiling lithium-7 nuclei. A large number of 10 Boron (10B) atoms have to be localized on or within neoplastic cells for BNCT to be effective, and an adequate number of thermal neutrons have to be absorbed by the 10B atoms to maintain a lethal 10B (n, a) lithium-7 reaction. The most exclusive property of BNCT is that it can deposit an immense dose gradient between the tumour cells and normal cells. BNCT integrates the fundamental focusing perception of chemotherapy and the gross anatomical localization proposition of traditional radiotherapy.
- Subjects
BORON-neutron capture therapy; STABLE isotopes; NEOPLASTIC cell transformation
- Publication
Journal of Clinical & Diagnostic Research, 2016, Vol 10, Issue 12, p1
- ISSN
0973-709X
- Publication type
Article
- DOI
10.7860/JCDR/2016/19890.9024