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- Title
Cell Cycle Regulators and Lineage-Specific Therapeutic Targets for Cushing Disease.
- Authors
Araki, Takako; Liu, Ning-Ai
- Abstract
Cell cycle proteins are critical to pituitary development, but their contribution to lineage-specific tumorigenesis has not been well-elucidated. Emerging evidence from in vitro human tumor analysis and transgenic mouse models indicates that G1/S-related cell cycle proteins, particularly cyclin E, p27, Rb, and E2F1, drive molecular mechanisms that underlie corticotroph-specific differentiation and development of Cushing disease. The aim of this review is to summarize the literature and discuss the complex role of cell cycle regulation in Cushing disease, with a focus on identifying potential targets for therapeutic intervention in patients with these tumors.
- Subjects
CELL cycle proteins; CUSHING'S syndrome treatment; MOLECULAR mechanisms of immunosuppression; CYCLIN E; TARGETED drug delivery; THERAPEUTICS
- Publication
Frontiers in Endocrinology, 2018, pN.PAG
- ISSN
1664-2392
- Publication type
Article
- DOI
10.3389/fendo.2018.00444