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- Title
Anti-MOG Positive Bilateral Optic Neuritis and Brainstem Encephalitis Secondary to COVID-19 Infection: A Case Report.
- Authors
Tsouris, Zisis; Provatas, Antonios; Bakirtzis, Christos; Aloizou, Athina-Maria; Siokas, Vasileios; Tsimourtou, Vana; Grigoriadis, Nikolaos; Hadjigeorgiou, Georgios M.; Dardiotis, Efthimios
- Abstract
(1) Introduction: There have been numerous reports on the neuroinvasive competence of SARS-CoV-2. Here, we present a case with anti-MOG positive bilateral optic neuritis and brainstem encephalitis secondary to COVID-19 infection. Additionally, we present a review of the current literature regarding the manifestation of anti-MOG positive optic neuritis as well as anti-MOG positive encephalitis after COVID-19 infection. (2) Case Report: A 59-year-old female patient, with a recent history of COVID-19 infection, presented a progressive reduction of visual acuity and bilateral retrobulbar pain for the last 20 days. An ophthalmological examination revealed a decreased visual acuity (counting fingers) and a bilateral papilledema. An MRI scan of the brain revealed a mild thickening of the bilateral optic nerves and high-intensity lesions in the medial and right lateral pons. A high titer of IgG and IgM antibodies against SARS-CoV-2 in serum and antibodies against myelin oligodendrocyte glycoprotein (anti-MOG) in serum and CSF were revealed. The diagnosis of anti-MOG brainstem encephalitis and optic neuritis was set. (3) Conclusions: The history of COVID-19 infection should raise awareness about these autoimmune and infection-triggered diseases, such as anti-MOG antibody disease.
- Subjects
OPTIC neuritis; ANTI-NMDA receptor encephalitis; COVID-19; COVID-19 pandemic; MYELIN oligodendrocyte glycoprotein; BRAIN stem
- Publication
Neurology International, 2022, Vol 14, Issue 4, p991
- ISSN
2035-8377
- Publication type
Article
- DOI
10.3390/neurolint14040078