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- Title
Topiramate add-on treatment associated with normalization of prolactin levels in a patient with schizophrenia.
- Authors
Yinglin Huang; Huan Ma; Yuan Wang; Miao Peng; Gang Zhu
- Abstract
Topiramate has been used increasingly in the management of psychiatric conditions. Clinical trials demonstrated that topiramate augmentation was effective in controlling negative symptoms in schizophrenia. This case report presents a case of a 38-year-old man with schizophrenia who achieved full negative symptom remission upon the adjunctive use of topiramate. However, the remarkable finding of this case is the concomitant decrease in the level of prolactin when topiramate (50 mg/day) was started and the rebound after discontinuation of topiramate. Previous studies stated that topiramate could prevent antipsychotic-induced weight gain and adverse metabolic effects. To the authors' knowledge, no study has reported that topiramate augmentation could be a treatment strategy for antipsychotic-induced hyperprolactinemia. This finding could be verified by well-designed clinical trials.
- Subjects
SCHIZOPHRENIA; TOPIRAMATE; SCHIZOPHRENIA treatment; PROLACTIN; DRUG efficacy; CLINICAL trials; THERAPEUTICS; CASE studies
- Publication
Neuropsychiatric Disease & Treatment, 2017, Vol 13, p1395
- ISSN
1176-6328
- Publication type
Case Study
- DOI
10.2147/NDT.S135666