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- Title
Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPAR&α Involvement in Hair Growth.
- Authors
Billoni, Nelly; Buan, Bruno; Gautier, Brigitte; Collin, Christine; Gaillard, Olivier; Mahé, Yann F.; Bernard, Bruno A.
- Abstract
Peroxisome proliferator-activated receptors (PPARs), which belong to the nuclear hormone receptor superfamily, have recently been described as potent key regulators of epidermal development. As 1,25-dihydroxyvitamin D[sub 3], retinoic acid and triiodothyronine are known to exert effects on skin and hair follicle growth through similar receptors, we decided to investigate both the expression pattern of the PPARα, -δ and -γ subtypes and their role in human hair follicles. Using reverse transcriptase-polymerase chain reaction and immunohistochemistry, we established that PPAR α, -δ and -γ were expressed in both dermal and epithelial human hair follicle cells. Additionally, we evaluated the dose effect of clofibrate, a PPARα ligand, on the survival of human hair follicles in culture. A beneficial effect was observed within a narrow range of concentrations.
- Subjects
PEROXISOMES; HAIR follicles
- Publication
Acta Dermato-Venereologica, 2000, Vol 80, Issue 5, p329
- ISSN
0001-5555
- Publication type
Article
- DOI
10.1080/000155500459240