We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo.
- Authors
Hoteiya, Toshiaki; Hayashi, Eiji; Satomura, Kazuhito; Kamata, Nobuyuki; Nagayama, Masaru; Hoteiya, T; Hayashi, E; Satomura, K; Kamata, N; Nagayama, M
- Abstract
We examined the expression of E-cadherin in nine oral cancer cell lines. HSC-4, NA, ZA, HOC927 and Ca9-22 cells strongly expressed E-cadherin [E-CD(++) cell line] and HSC-2 and HSC-3 cells weakly expressed E-cadherin [E-CD(+) cell line]. All the cell lines that expressed E-cadherin were of cuboidal morphology and formed cobblestone colonies. In contrast, TSU and HOC313 cells had spindle shapes, formed dispersed colonies, and were completely negative for E-cadherin [E-CD(-) cell line]. Moreover, all cell lines that expressed E-cadherin showed tumorgenicity in SCID mice, but E-CD(-) cell lines did not show tumorgenicity. The tumors derived from E-CD(+) cell lines invaded deeper into the connective tissues than those from E-CD(++) cell lines. In immunohistochemical analysis, the difference was more marked at the edges of the cancer nests. These results suggest that E-cadherin expression was relevant to the cell forms and the differential grade of cultured cells and that reduced E-cadherin in oral cancer may be associated with invasiveness in vivo.
- Subjects
CELL adhesion molecules; CANCER cells; CELL lines; LYMPH node cancer; ORAL cancer; PRECANCEROUS conditions
- Publication
Journal of Oral Pathology & Medicine, 1999, Vol 28, Issue 3, p107
- ISSN
0904-2512
- Publication type
journal article
- DOI
10.1111/j.1600-0714.1999.tb02006.x