We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Akutno zatajenje jetre i transplantacija.
- Authors
Aničić, Mirna Natalija; Omerza, Lana; Senečić-Čala, Irena; Tješić-Drinković, Duška; Vuković, Jurica
- Abstract
Acute liver failure is a progressive clinical syndrome characterized by the rapid onset of liver dysfunction with consequent dysfunction of other organ systems. The diagnostic criteria differ from adults because the development of liver encephalopathy, especially in the early stages, is not easy to recognize, especially in newborns and infants, and it may not be present initially, so it is not necessary for diagnosis. The causes of acute liver failure are numerous and age dependent, and in almost 50% of cases despite exhaustive diagnostic testing the cause remains unknown. The clinical picture in children is often nonspecific (fatigue, myalgia, abdominal pain, nausea, and vomiting), and jaundice may or may not be present immediately. In the early stages of the disease, physical and neurological status can be completely normal, but knowing the unpredictability of this condition, which can result in multiorgan failure and coma in a few hours, it is crucial to transport the patient promptly to the transplant center. Patient care is led by a multidisciplinary team, and takes place in the Intensive care unit due to the possibility of continuous monitoring of vital functions and neurological status. Although a small proportion of patients achieve full recovery with symptomatic treatment, most still require a liver transplant. What is the optimal time for a liver transplant and whether it is really needed or there is a possibility of spontaneous recovery, are eternal questions for the doctors who care for such patients. Until a good prognostic model for predicting survival with or without transplant is established, we are left with an individual assessment of each case.
- Subjects
NEWBORN infants; LIVER transplantation; TRANSPORTATION of patients; INTENSIVE care units; PHYSICIANS; CEREBRAL anoxia-ischemia
- Publication
Paediatria Croatica, Supplement, 2022, Vol 144, p21
- ISSN
1330-724X
- Publication type
Article
- DOI
10.26800/LV-144-supl1-5