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- Title
Generalized Pustular Psoriasis in Patients with Interferon Gamma (IFN-γ) Receptor Deficiency and Mycobacterial Infection.
- Authors
Xiao, Haijuan; Guo, Xin; Hu, Bing; Liu, Jinrong; Zhao, Shunying; Xu, Zhe; Zhang, Nan; He, Lejian; Liu, Yan; Liu, Linlin; Li, Shaoying; Li, Wei; Liu, Gang
- Abstract
Some papers have shown psoriasis in patients receiving BCG vaccination or intravesical BCG immunotherapy, but no cases of GPP have been reported [[12]]. However, considering that topical corticosteroids were ever used for GPP and that ertapenem briefly cleared most pustules in patient 2, we could not rule out the possibility that secondary bacterial infection aggravated the GPP lesions [[16]]. Antitubercular therapy might block related inflammatory responses by inhibiting mycobacteria in patients with IFN- R deficiency, thus treating GPP. Herein, we report two patients with partial IFN- R1 deficiency and complete IFN- R2 deficiency, respectively, who developed severe GPP relieved by antitubercular treatment.
- Subjects
MYCOBACTERIAL diseases; INTERFERON gamma; PSORIASIS; LEUKOCYTOCLASTIC vasculitis; CELL receptors; MULTIDRUG-resistant tuberculosis; LEG pain
- Publication
Journal of Clinical Immunology, 2021, Vol 41, Issue 4, p829
- ISSN
0271-9142
- Publication type
Letter
- DOI
10.1007/s10875-020-00934-z