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- Title
Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes.
- Authors
Kuo, Wen-Shuo; Wang, Jiu-Yao; Chang, Chia-Yuan; Liu, Jui-Chang; Shao, Yu-Ting; Lin, Yen-Sung; So, Edmund Cheung; Wu, Ping-Ching
- Abstract
We successfully prepared water-soluble fullerenol [C60(OH)46] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C60(OH)46 with a higher composition of exposed hydroxyl groups had superior two-photon stability and characteristics compared with that with a lower composition of such groups. Therefore, the prepared fullerenol can be an effective two-photon photosensitizer. The water-soluble C60(OH)46 had favorable two-photon properties. During two-photon photodynamic therapy, the water-soluble C60(OH)46 had substantial antimicrobial activity against Escherichia coli at an ultralow-energy level of 211.2 nJ pixel−1 with 800 scans and a photoexcited wavelength of 760 nm.
- Subjects
REACTIVE oxygen species; PHOTODYNAMIC therapy; HYDROXYL group; PHOTOEXCITATION; ESCHERICHIA coli; MICROORGANISMS; PHOTOSENSITIZERS
- Publication
Nanoscale Research Letters, 2020, Vol 15, Issue 1, p1
- ISSN
1931-7573
- Publication type
Article
- DOI
10.1186/s11671-020-03329-6