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- Title
Profil immunoanalytique des anticorps anti-thyroglobuline.
- Authors
Doggui, Radhouene
- Abstract
The anti-thyroglobulin autoantibodies are endogenous molecules directed against specific epitopes of thyroglobulin. These antibodies are linked to the autoimmune diseases or the differentiated thyroid cancer. The occurrence of anti-thyroglobulin autoantibodies may introduce inaccuracies in thyroglobulin quantification, causing over- or underestimation depending on the used method. Consequently, their determination is important to validate the thyroglobulin measurement. These antibodies are increasingly used for the diagnosis of cancer recidivies during post-surgical phase or for the treatment and monitoring of patient with differentiated thyroid cancer, while a continuing debate as regard their efficiency. Despite the elaboration of a reference material MRC 65/93 since forty years approximatively, discrepancies between techniques still reported in the literature. In this work, after a physiological and structural reminder of the anti-thyroglobulin autoantibodies, we will discuss the important points related to the both preanalytical and analytical steps.
- Publication
Annales de Biologie Clinique, 2018, Vol 76, Issue 6, p695
- ISSN
0003-3898
- Publication type
Article
- DOI
10.1684/abc.2018.1383