We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Interictal Type 1 Cannabinoid Receptor Binding is Increased in Female Migraine Patients.
- Authors
Van der Schueren, Bart J.; Van Laere, Koen; Gérard, Nathalie; Bormans, Guy; De Hoon, Jan N.
- Abstract
Objective.- To compare binding of the type 1 cannabinoid receptor (CB1R) between migraine patients and healthy volunteers Background.- It has been suggested that endocannabinoid deficiency may play a role in the pathophysiology of migraine. Nonetheless, biochemical studies substantiating this idea remain scarce and are faced with methodological shortcomings partly because of the difficulty to perform measurements of endocannabinoids within the central nervous system itself. Methods.- An observational cross-sectional study was conducted in 20 female migraine patients and 18 healthy women matched for age and body mass index. Positron emission tomography acquisition was performed 90 minutes after intravenous injection of the radioligand [18F]MK-9470 to assess binding of [18F]MK-9470 to CB1R. Results.- Binding of CB1 R was globally increased in migraine patients vs healthy controls (average gray matter difference +16%; P = .009, 2-sample 2-sided Student's t-test). There were no correlations between CB1R binding and any predefined migraine characteristics. Increases in CB1R binding were most pronounced in the anterior cingulate, mesial temporal, prefrontal, and superior frontal cortices. Conclusion.- The increased interictal CB1R binding, especially in brain regions that exert top-down influences to modulate pain, supports the idea that endocannibinoid deficiency is present in female patients suffering from episodic migraine. ( Headache 2012;52:433-440)
- Subjects
ANALYSIS of variance; CANNABIS (Genus); CELL receptors; MIGRAINE; SCIENTIFIC observation; T-test (Statistics); POSITRON emission tomography; STATISTICAL power analysis; BODY mass index; CROSS-sectional method; DESCRIPTIVE statistics
- Publication
Headache: The Journal of Head & Face Pain, 2012, Vol 52, Issue 3, p433
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/j.1526-4610.2011.02030.x