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- Title
Tumour-Like Localized Amyloid of the Brain is derived from Immunoglobulin Light Chain.
- Authors
Eriksson, L.; Sletten, K.; Benson, L.; Westermark, P.
- Abstract
A patient is presented in whom the amyloid component of an intracerebral 'amyloidoma' has been purified and characterized by amino acid sequence analysis. The material originated from an autopsy of a 76-year-old man who 15 years earlier had been operated for an intracerebral 'amyloid tumour'. The tumour had recurred and grown to an almost walnut-sized mass in the right cerebral hemisphere. It was located in the parietal lobe close to the lateral ventricle and had a close connection to the choroid plexus. Histological examination showed large masses of amyloid surrounded by some plasma cells and a few macrophages of the foreign body type. Amino acid sequence analysis of a major fibril subunit protein showed homology with the variable region of a monoclonal lambda immunoglobulin light chain, subgroup III or IV. This shows that the amyloid in the 'tumour' was of AL type and presumably derived from local synthesis by plasma cells.
- Subjects
AMYLOID; AMINO acids; TUMORS; PLASMA cells; IMMUNOGLOBULINS; HOMOLOGY (Biology)
- Publication
Scandinavian Journal of Immunology, 1993, Vol 37, Issue 6, p623
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1993.tb01673.x