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- Title
The fluorescence of thyroid tissue
- Authors
Pitman, Michael Jay; Rosenthal, Joshua Michael; Savage, Howard E.; Yu, Goupei; McCormick, Steven A.; Katz, Alvin; Alfano, Robert R.; Schantz, Stimson Pryor
- Abstract
To investigate the fluorescent characteristics of different thyroid tissues.Fresh ex vivo thyroid tissue was surfaced scanned with a fluorescence spectrophotometer. Resultant spectra were evaluated via interpeak ratios.Interpeak ratios of all histologies were found to be significantly different from each other (P < 0.001). The diagnostic sensitivity and specificity of fluorescent spectroscopy was 86% and 91% for thyroid nodule capsule, 78% and 59% for papillary thyroid carcinoma, and 82% and 63% for normal thyroid, respectively.Fluorescent spectroscopy can been used to identify significant differences in the fluorescent characteristics of various thyroid histologies.This study is the first investigation of the fluorescence of thyroid tissue. The diagnostic ability of fluorescent spectrometry may allow it to be used as a localization aid for fine needle aspiration, using optical fiber probes. Further investigations may enhance the sensitivity and specificity of fluorescent spectrometry allowing it to replace or compliment fine needle aspiration. EBM rating: B-3.
- Subjects
ANATOMY; TISSUES; FLUORESCENCE; SURGERY
- Publication
Otolaryngology-Head & Neck Surgery, 2004, Vol 131, Issue 5, p623
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1016/j.otohns.2004.05.014