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- Title
An allele at the triose phosphate isomerase, Tpi-1 locus on chromosome 6 recovered from feral mice.
- Authors
Bulfield, Grahame; Ball, Simon T.; Peters, Josephine
- Abstract
An animal with low erythrocyte triose phosphate isomerase (TPI) activity was found amongst mice trapped on a farm in Leicestershire. The low TPI activity was caused by the segregation of a single co-dominant gene which also affected the Km for glyceraldehyde-3-phosphate and heat stability of the enzyme. We designate the gene Tpi-1, the structural locus for TPI, with the a allele in the common inbred strains and the b allele derived from the wild-caught mouse. Tpi-1 was known to be on chromosome 6 by somatic cell techniques and, as shown in a preliminary report (Peters & Bulfield, 1984), we have confirmed and extended this finding using three chromosome-6 marker genes giving the order: Sig-28-Lc-11-Miwh-16-Tpi-1.
- Publication
Genetics Research, 1987, Vol 50, Issue 3, p239
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300023764