We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of a single human leucocyte antigen ( HLA) allele mismatch on the outcome of unrelated bone marrow transplantation over two time periods. A retrospective analysis of 3003 patients from the HLA Working Group of the Japan Society for Blood and Marrow Transplantation
- Authors
Kanda, Yoshinobu; Kanda, Junya; Atsuta, Yoshiko; Maeda, Yoshinobu; Ichinohe, Tatsuo; Ohashi, Kazuteru; Fukuda, Takahiro; Miyamura, Koichi; Iida, Hiroatsu; Mori, Takehiko; Iwato, Koji; Eto, Tetsuya; Kawa, Keisei; Morita, Satoshi; Morishima, Yasuo
- Abstract
A previous Japanese study revealed that a human leucocyte antigen ( HLA)- A or - B allele mismatch was associated with higher overall mortality, whereas an HLA-C or - DRB1 allele mismatch did not affect mortality after serologically matched unrelated bone marrow transplantation ( BMT). This study reanalysed 3003 adult patients who underwent unrelated BMT from a serologically HLA- A, - B, or - DR matched unrelated donor between 1993 and 2009 using the latest database, that included 1966 HLA-matched unrelated BMT and 187, 31, 524, and 295 unrelated BMT with a single HLA- A, - B, - C, or - DRB1 allele mismatch, respectively. As opposed to our previous findings, HLA- C and - DRB1 mismatches had a significant negative impact [hazard ratio ( HR) 1·35, P < 0·001, and HR 1·45, P < 0·001] on survival in the period 2000-2009. The negative impact of each single HLA allele mismatch was not significantly different among the HLA- A, - B, - C, and - DRB1 mismatches ( P = 0·79). An interaction test revealed that the effects of single HLA- C and - DRB1 allele mismatches significantly differed over the two time periods ( P = 0·032 and P = 0·0072, respectively). In conclusion, the impact of a single HLA allele mismatch changed over time. In the recent cohort, the negative impact of HLA- DRB1 and - C mismatches became apparent.
- Subjects
JAPAN; HLA histocompatibility antigens; ALLELES; BONE marrow transplantation; RETROSPECTIVE studies; SEROLOGY; MORTALITY
- Publication
British Journal of Haematology, 2013, Vol 161, Issue 4, p566
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.12279