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- Title
Prevention of β-Lactam-Associated Diarrhea by Saccharomyces boulardii Compared with Placebo.
- Authors
McFarland, Lynne V.; Surawicz, Christina M.; Greenberg, Richard N.; Elmer, Gary W.; Moyer, Kris A.; Melcher, Sally A.; Bowen, Karen E.; Cox, Jenny L.
- Abstract
Objectives: To determine the safety and efficacy of a new preventive agent for antibiotic-associated diarrhea (AAD) in patients receiving at least one β-lactam antibiotic. Methods: A double-blinded, placebo-controlled, parallel group study was performed in a high-risk group of hospitalized patients receiving a new prescription for a β-lactam antibiotic and having no acute diarrhea on enrollment. Lyophilized <em>Saccharomyces boulardii</em> or placebo (1 g/day) was given within 72 h of the start of the antibiotic(s) and continued until 3 days after the antibiotic was discontinued, after which the patients were followed for 7 wk. Results: Of the 193 eligible patients, significantly fewer, 7/97 (7.2%), patients receiving S. boulardii developed AAD compared with 14/96 (14.6%) on placebo (<em>p</em> = 0.02). The efficacy of <em>S. boulardii</em> for the prevention of AAD was 51%. Using a multivariate model to adjust for two independent risk factors for AAD Cage and days of cephalosporin use), the adjusted relative risk was significantly protective for <em>S. boulardii</em> (RR = 0.29, 95% C) = 0.08, 0.98). Conclusion: The prophylactic use of <em>S. boulardii</em> given with a β-lactam antibiotic resulted in a significant reduction of AAD with no serious adverse reactions.
- Subjects
DIARRHEA; SACCHAROMYCES; LACTAMS; PLACEBOS; TOXIN receptors
- Publication
American Journal of Gastroenterology (Springer Nature), 1995, Vol 90, Issue 3, p439
- ISSN
0002-9270
- Publication type
Article