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- Title
Vitamin D supplementation for prevention of cancer: the D2d cancer outcomes (D2dCA) ancillary study.
- Authors
Chatterjee, Ranee; Fuss, Paul; Vickery, Ellen M.; LeBlanc, Erin S.; Sheehan, Patricia R.; Lewis, Michael R.; Dolor, Rowena J.; Johnson, Karen C.; Kashyap, Sangeeta R.; Nelson, Jason; Pittas, Anastassios G.; D2d Research Group
- Abstract
<bold>Context: </bold>Observational studies suggest that low vitamin D status may be a risk factor for cancer.<bold>Objectives: </bold>In a population with prediabetes and overweight/obesity that is at higher risk of cancer than the general population, we sought to determine if vitamin D supplementation lowers risk of cancer and precancers.<bold>Design: </bold>The D2d cancer outcomes study (D2dCA) is an ancillary study to the Vitamin D and type 2 diabetes (D2d) study.<bold>Setting: </bold>Twenty-two US academic medical centers.<bold>Participants: </bold>Participants had prediabetes and overweight/obesity and were free of cancer for the previous 5 years.<bold>Interventions: </bold>Vitamin D3 4000 IU daily or placebo.<bold>Main Outcomes: </bold>At scheduled study visits (four times/year), cancer and precancer outcomes were identified by questionnaires. Clinical data were collected and adjudicated for all reported events. Cox proportional hazard models compared the hazard ratio (HR) of incident cancers and precancers between groups.<bold>Results: </bold>Over a median follow-up of 2.9 years, among 2385 participants (mean age 60 years and 25-hydroxyvitamin D 28 ng/mL), there were 89 cases of cancer. The HR of incident cancer for vitamin D vs. placebo was 1.07 (95% CI: 0.70, 1.62). Of 241 participants with incident precancers, 239 had colorectal adenomatous polyps. The HR for colorectal polyps for vitamin D vs. placebo was 0.83 (95% CI: 0.64, 1.07).<bold>Conclusions: </bold>In the D2d population of participants with prediabetes and overweight/obesity not selected for vitamin D insufficiency, vitamin D supplementation did not have a significant effect on risk of incident cancer or colon polyps.
- Subjects
VITAMIN D; CALCIUM supplements; DIETARY supplements; CANCER prognosis; CANCER prevention; CHOLECALCIFEROL; OBESITY complications; TUMOR prevention; RESEARCH; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; RESEARCH funding; PREDIABETIC state; PROPORTIONAL hazards models; PRECANCEROUS conditions; DISEASE complications
- Publication
Journal of Clinical Endocrinology & Metabolism, 2021, Vol 106, Issue 9, p2767
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgab153