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- Title
Evaluation of Color Discrimination Ability in Patients with Transfusion Dependent Beta Thalassemia by Farnsworth Munsell 100 Hue Test.
- Authors
Koçtekin, Belkıs; Doğan, Berna; Karakuş, Volkan; Erdem, Ramazan; Büber, Hakan; Kurtoğlu, Erdal
- Abstract
AIM: It has come to our attention that color vision, which is reported to be impaired in transfusion-dependent beta thalassemia (TDß-T) patients, is frequently examined with screening tests used for congenital color vision defects. We aimed to detailed examine color discrimination ability (CDA) in patients with TDß-T by Farnsworth Munsell (FM) 100 hue test recommended for acquired color vision disorders. METHODS: This prospective croOC-sectional study was conducted between January and June, 2022 in a tertiary hospital. Forty-two TBß-T patients and 15 healthy individuals were included. All participants underwent a detailed ophthalmological examination. Subjects with any disease that may affect visual functions were excluded. Screening for congenital color vision deficiency was performed by the Ishıhara test. FM100 hue test is an arranging test based on ordering colored caps correctly and is evaluated on error scores. Total error score (TES), blue-yellow local error score (b-y LES), and red-green local error score (r-g LES) were calculated according to performed ordering in the study. SPSS 23 program was used for statistical analysis. RESULTS: Eighty-three eyes of 42 patients (30.12±6.79 years) and 30 eyes of 15 healthy individuals (34.30±6.18 years) were included in the study. All patients were dependent on red blood cell transfusion every 2-3 weeks and were using iron-binding drugs. Hemoglobin levels were lower and ferritin levels were higher in patients compared to controls (p<0.001). TES, b-y LES, and r-g LES were detected significantly higher in patients than in controls (p<0.001). TES; 63.35±31.60 vs 29.77±15.03, b-y LES; 33.26±18.24 vs 15.73±9.50 and r-g LES; 28.79±16.13 vs 13.23±7.47. b-y LES was significantly higher than r-g LES in patients (p=0.015), but no difference in controls. CONCLUSION: The disease itself, tissue hypoxia, iron overload, or toxicity of iron-binding drugs may have affected color vision. More extensive studies are needed to understand the underlying mechanisms.
- Subjects
COLOR vision; BETA-Thalassemia; RED blood cell transfusion; BLOOD transfusion; COLOR blindness; ALLOIMMUNITY
- Publication
Acta Physiologica, 2023, Vol 237, p43
- ISSN
1748-1708
- Publication type
Article