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- Title
Antidepressant-Like and Antioxidant Effects of Plinia trunciflora in Mice.
- Authors
Sacchet, Cassia; Mocelin, Ricieri; Sachett, Adrieli; Bevilaqua, Fernanda; Chitolina, Rafael; Kuhn, Fernanda; Boligon, Aline Augusti; Athayde, Margareth Linde; Roman Junior, Walter Antonio; Broock Rosemberg, Denis; Dal Magro, Jacir; Marafiga Conterato, Greicy Michelle; Piato, Angelo L.
- Abstract
The jaboticaba tree, Plinia trunciflora (O. Berg) Kausel, is popularly named "jabuticabeira" in Brazil and is used in folk medicine to treat diabetes and chronic inflammation of the tonsils, but studies evaluating the central effects of this species are limited. This study evaluated the antidepressant-like and antioxidant effects of P. trunciflora (PT) aqueous extract, in which five different anthocyanins were identified. PT showed significant ferric-reduction power and DPPH radical scavenging activity in vitro and reduced lipid peroxidation both in vitro and ex vivo. At the behavioural level, PT (400 and 800mg/kg, i.p.) dose-dependently reduced immobility time in the tail suspension test in Swiss male mice. The identification of bioactive compounds accompanied by the in vitro and ex vivo antioxidant activity of PT suggests that these activities might be related to the antidepressant-like activity of P. trunciflora.
- Subjects
ANTIDEPRESSANTS; MENTAL depression; PROTEIN metabolism; ANIMAL experimentation; ANTIOXIDANTS; BIOPHYSICS; FRUIT; IRON compounds; RESEARCH methodology; LIPID peroxidation (Biology); MICE; PHENOLS; STATISTICS; T-test (Statistics); PLANT extracts; DATA analysis; OXIDATIVE stress; DATA analysis software; FREE radical scavengers; ONE-way analysis of variance
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2015, p1
- ISSN
1741-427X
- Publication type
journal article
- DOI
10.1155/2015/601503