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- Title
Association between single nucleotide polymorphism of rs1937 in TFAM gene and longevity among the elderly Chinese population: based on the CLHLS study.
- Authors
Chen, Qing; Li, Zhi-Hao; Song, Wei-Qi; Yao, Yao; Zhang, Yu-Jie; Zhong, Wen-Fang; Zhang, Pei-Dong; Liu, Dan; Zhang, Xi-Ru; Huang, Qing-Mei; Zhao, Xiao-Yang; Shi, Xiao-Ming; Mao, Chen
- Abstract
<bold>Background: </bold>To investigate whether the mitochondrial transcription factor A (TFAM) rs1937 single nucleotide polymorphism (SNP) is associated with longevity.<bold>Methods: </bold>We conducted a case-control study among Chinese long-lived individuals (≥90 years). Data were obtained on 3294 participants who were able to voluntarily provided a saliva sample during 2008-2009 from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). In this study, 1387 young elderly (65-74 years) were allocated to the control group, and 1907 long-lived individuals were recruited as the case group. SNP rs1937 on TFAM were genotyped. Logistic regression models were applied to evaluate the association between rs1937 SNP and longevity.<bold>Results: </bold>The genotype frequency of the SNP of rs1937 in the two groups had a significant difference (p = 0.003). Binary logistic regression analysis showed that compared to younger elderly, the long-lived individuals with "CC genotype" of rs1937 were more closely related to increased longevity than those with "GG genotype" (OR: 1.989, 95% CI: 1.160-3.411). The positive association between rs1937 SNP and longevity was robust in stratified analyses and sensitivity analyses.<bold>Conclusions: </bold>We found the SNP of rs1937 may be a potential biomarker for longer human life span. Further studies are necessary to elucidate the biological mechanism of rs1937 on TFAM with promoting longevity.
- Subjects
SINGLE nucleotide polymorphisms; OLDER people; CHINESE people; LONGEVITY; LOGISTIC regression analysis; LIFE spans
- Publication
BMC Geriatrics, 2022, Vol 22, Issue 1, p1
- ISSN
1471-2318
- Publication type
journal article
- DOI
10.1186/s12877-021-02655-3