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- Title
The effect of BIS-guided anaesthesia on the incidence of postoperative nausea and vomiting in children: a prospective randomized double-blind study.
- Authors
Frelich, Michal; Sklienka, Peter; Romanová, Tereza; Němcová, Simona; Bílená, Markéta; Straková, Hana; Lečbychová, Karolína; Jor, Ondřej; Formánek, Martin; Burša, Filip
- Abstract
Background: Postoperative nausea and vomiting (PONV) is a significant problem following paediatric surgery, and volatile anaesthetics are an important cause of this phenomenon. BIS-guided anaesthesia, by reducing the consumption of anaesthetics, leads to a decrease in PONV in adult patients. Study objective: Evaluate the role of BIS-guided anaesthesia in reducing the incidence of paediatric PONV. Design: Prospective, randomized, double-blind study. Setting: A single center study in university hospital in Czech republic, from June 2021 to November 2022. Patients: A total of 163 children, aged 3–8 years with ASA I-II who underwent endoscopic adenoidectomy under general anaesthesia were included. Interventions: In the intervention group, the depth of anaesthesia was maintained to values between 40 and 60 of BIS. Main outcome measure: The primary outcome was the incidence of postoperative nausea and vomiting during 24 h after surgery. Results: The use of BIS-guided anaesthesia led to a significant decrease in the incidence of nausea and vomiting compared to the control group [17% vs. 53%; RR (95%CI) 0.48 (0.27–0.86); p < 0.001and 16% vs. 34%; RR (95%CI) 0.33 (0.20–0.54); p = 0.01, respectively]. Conclusions: BIS-guided anaesthesia decreases the incidence of postoperative nausea and vomiting in children undergoing adenoidectomy. Trial registration: Clinicaltrials.gov identifier: NCT04466579.
- Subjects
CZECH Republic; PREVENTION of surgical complications; VOMITING prevention; RESEARCH funding; BLIND experiment; INTRAVENOUS anesthetics; TREATMENT effectiveness; RANDOMIZED controlled trials; DESCRIPTIVE statistics; SURGICAL complications; LONGITUDINAL method; INTRAVENOUS anesthesia; PATIENT monitoring; VOMITING; COMPARATIVE studies; GENERAL anesthesia; CONFIDENCE intervals; ANESTHESIA; NAUSEA; PHARMACODYNAMICS; EVALUATION; CHILDREN
- Publication
BMC Anesthesiology, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2253
- Publication type
Article
- DOI
10.1186/s12871-024-02610-w