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- Title
Development and validation of a predictive risk factor model for epidural re-siting in women undergoing labour epidural analgesia: a retrospective cohort study.
- Authors
Lee, John Song En; Sultana, Rehena; Han, Nian Lin Reena; Sia, Alex Tiong Heng; Sng, Ban Leong
- Abstract
Background: Epidural catheter re-siting in parturients receiving labour epidural analgesia is distressing to the parturient and places them at increased complications from a repeat procedure. The aim of this study was to develop and validate a clinical risk factor model to predict the incidence of epidural catheter re-siting in labour analgesia. Methods: The data from parturients that received labour epidural analgesia in our centre during 2014–2015 was used to develop a predictive model for epidural catheter re-siting during labour analgesia. Multivariate logistic regression analysis was used to identify factors that were predictive of epidural catheter re-siting. The forward, backward and stepwise variable selection methods were applied to build a predictive model, which was internally validated. The final multivariate model was externally validated with the data collected from 10,170 parturients during 2012–2013 in our centre. Results: Ninety-three (0.88%) parturients in 2014–2015 required re-siting of their epidural catheter. The training data set included 7439 paturients in 2014–2015. A higher incidence of breakthrough pain (OR = 4.42), increasing age (OR = 1.07), an increased pain score post-epidural catheter insertion (OR = 1.35) and problems such as inability to obtain cerebrospinal fluid in combined spinal epidural technique (OR = 2.06) and venous puncture (OR = 1.70) were found to be significantly predictive of epidural catheter re-siting, while spontaneous onset of labour (OR = 0.31) was found to be protective. The predictive model was validated internally on a further 3189 paturients from the data of 2014–2015 and externally on 10,170 paturients from the data of 2012–2013. Predictive accuracy of the model based on C-statistic were 0.89 (0.86, 0.93) and 0.92 (0.88, 0.97) for training and internal validation data respectively. Similarly, predictive accuracy in terms of C-statistic was 0.89 (0.86, 0.92) based on 2012–2013 data. Conclusion: Our predictive model of epidural re-siting in parturients receiving labour epidural analgesia could provide timely identification of high-risk paturients required epidural re-siting.
- Subjects
AGE distribution; CATHETERIZATION; LONGITUDINAL method; MULTIVARIATE analysis; RESEARCH evaluation; RISK assessment; OPERATIVE surgery; MULTIPLE regression analysis; DISEASE incidence; RETROSPECTIVE studies; EPIDURAL catheters; EPIDURAL analgesia; OBSTETRICAL analgesia; BREAKTHROUGH pain; ODDS ratio
- Publication
BMC Anesthesiology, 2018, Vol 18, Issue 1, pN.PAG
- ISSN
1471-2253
- Publication type
Article
- DOI
10.1186/s12871-018-0638-x