We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The β‐adrenergic hypothesis of synaptic and microglial impairment in Alzheimer's disease.
- Authors
Li, Shaomin
- Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disease originating partly from amyloid β protein‐induced synaptic failure. As damaging of noradrenergic neurons in the locus coeruleus (LC) occurs at the prodromal stage of AD, activation of adrenergic receptors could serve as the first line of defense against the onset of the disease. Activation of β2‐ARs strengthens long‐term potentiation (LTP) and synaptic activity, thus improving learning and memory. Physical stimulation of animals exposed to an enriched environment (EE) leads to the activation of β2‐ARs and prevents synaptic dysfunction. EE also suppresses neuroinflammation, suggesting that β2‐AR agonists may play a neuroprotective role. The β2‐AR agonists used for respiratory diseases have been shown to have an anti‐inflammatory effect. Epidemiological studies further support the beneficial effects of β2‐AR agonists on several neurodegenerative diseases. Thus, I propose that β2‐AR agonists may provide therapeutic value in combination with novel treatments for AD.
- Subjects
LOCUS coeruleus; ALZHEIMER'S disease; NORADRENERGIC neurons; ADRENERGIC receptors; LONG-term potentiation; MICROGLIA
- Publication
Journal of Neurochemistry, 2023, Vol 165, Issue 3, p289
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1111/jnc.15782