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- Title
Human neural stem cells expressing carboxyl esterase target and inhibit tumor growth of lung cancer brain metastases.
- Authors
Hong, S H; Lee, H J; An, J; Lim, I; Borlongan, C; Aboody, K S; Kim, S U
- Abstract
Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to brain tumors. Human NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibit the growth of A549 human non-small cell lung adenocarcinoma cells in the presence of CPT-11 in vitro and in vivo. F3.CE cells migrated selectively into the brain metastases located in the opposite hemisphere. The treatment also significantly decreased tumor volume in immune-deficient mice bearing lung cancer when F3.CE cells were transplanted into the contralateral hemisphere. The survival of tumor-bearing animals was significantly prolonged by the treatment with F3.CE and CPT-11. This strategy could be considered as an effective treatment regimen for lung cancer brain metastases.
- Subjects
NEURAL stem cells; LUNG cancer; BRAIN metastasis; GENE therapy; ADENOCARCINOMA; ONCOLOGY
- Publication
Cancer Gene Therapy, 2013, Vol 20, Issue 12, p678
- ISSN
0929-1903
- Publication type
Article
- DOI
10.1038/cgt.2013.69