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- Title
Complementarity of structural biology methods: ribosome in the spotlight.
- Authors
Sengupta, Jayati
- Abstract
The translational apparatus ribosome is in the limelight these days with the announcement of the 2009 Nobel Prize in Chemistry. The three winners have unveiled ribosome structures using X-ray crystallography. Ribosome 3D structures have also been studied by another emerging structural biology method named cryo-electron microscopy (cryo-EM). In the study of the structure and function of macromolecules, the 'hybrid' strategy of combining available structural data derived from various sources has been proven quite successful. This review highlights how the hybrid approach in ribosome structure analysis paves the way for a more detailed molecular understanding of the structural basis of translation.
- Subjects
RIBOSOME structure; NOBEL Prizes; X-ray crystallography; ELECTRON microscopy; MACROMOLECULES; GENETIC translation
- Publication
Current Science (00113891), 2010, Vol 98, Issue 12, p1584
- ISSN
0011-3891
- Publication type
Article