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- Title
Progressive brachial plexus enlargement in hereditary transthyretin amyloidosis.
- Authors
Salvalaggio, Alessandro; Coraci, Daniele; Obici, Laura; Cacciavillani, Mario; Luigetti, Marco; Mazzeo, Anna; Pastorelli, Francesca; Grandis, Marina; Cavallaro, Tiziana; Bisogni, Giulia; Lozza, Alessandro; Gemelli, Chiara; Gentile, Luca; Russo, Massimo; Ermani, Mario; Fabrizi, Gian Maria; Plasmati, Rosaria; De Napoli, Federica; Campagnolo, Marta; Castellani, Francesca
- Abstract
Axonal polyneuropathy is the main feature of hereditary transthyretin amyloidosis (ATTRv). Nerve morphological abnormalities have been reported, but longitudinal changes have never been assessed. We performed a prospective widespread nerve ultrasound evaluation and nerve cross-sectional area (CSA) was compared with baseline data in both ATTRv patients and pre-symptomatic carriers. Thirty-eight subjects were evaluated (mean follow-up 17.1 months), among them 21 had polyneuropathy while 17 were pre-symptomatic carriers. CSA significantly increased at brachial plexus in both groups (p = 0.008 and p = 0.012) pointing to progressive brachial plexus enlargement as a longitudinal biomarker of both disease progression and disease occurrence in pre-symptomatic carriers.
- Subjects
BRACHIAL plexus; TRANSTHYRETIN; AMYLOIDOSIS; CARDIAC amyloidosis; PERIPHERAL nervous system; DISEASE progression
- Publication
Journal of Neurology, 2022, Vol 269, Issue 4, p1905
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-021-10754-9