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- Title
Prophylaxis with enoxaparin and antithrombin III in drug-induced coagulation alterations in childhood leukemia: a retrospective experience of 20 years.
- Authors
Salvador, Christina; Salvador, Robert; Kropshofer, Gabriele; Meister, Bernhard; Rock, Marie; Obexer, Petra; Hetzer, Benjamin; Rabensteiner, Evelyn; Crazzolara, Roman
- Abstract
Background: Thromboembolic complications are well known in the treatment of childhood acute lymphoblastic leukemia. Over the years it has not been possible to reach a consensus on a possible prophylaxis of thromboembolic events during intensive therapy. Only the administration of enoxaparin was able to achieve evidence in the literature to date. Methods: In this retrospective study, 173 childhood leukemia patients were treated over 20 years with a thromboembolic prophylaxis including enoxaparin and AT III during induction therapy with L-asparaginase and cortisone. Results: We here report the effectiveness of administration of enoxaparin and AT III in childhood leukemia, showing a strikingly low prevalence of deep vein thrombosis (2.9%). Especially in adolescent patients, a particularly great need for AT III was demonstrated. Conclusions: We recommend thromboembolic prophylaxis with enoxaparin and AT III substitution during induction/reinduction therapy with L-asparaginase and glucocorticosteroids, especially from adolescence onwards.
- Subjects
THROMBOEMBOLISM prevention; TUMORS in children; LOW-molecular-weight heparin; T-test (Statistics); FIBRIN; RETROSPECTIVE studies; DESCRIPTIVE statistics; LEUKEMIA; ENOXAPARIN; LONGITUDINAL method; INFERENTIAL statistics; DATA analysis software; CONFIDENCE intervals; REGRESSION analysis; CHILDREN
- Publication
Thrombosis Journal, 2024, Vol 22, Issue 1, p1
- ISSN
1477-9560
- Publication type
Article
- DOI
10.1186/s12959-024-00602-x