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- Title
Hematological Profile of Untreated or Ionizing Radiation-Exposed Cyclooxygenase-2-Deficient Mice.
- Authors
HOFER, M.; HOFEROVÁ, Z.; DUŠEK, L.; SOUČEK, K.; GRUZDEV, A.
- Abstract
We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of γ-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2-deficient mice compared to wildtype. To conclude, the anti-inflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure.
- Subjects
LABORATORY mice; MICE behavior; MICE physiology; REGULATION of hematopoiesis; PHYSIOLOGICAL effects of ionizing radiation; PARTICLE scattering functions
- Publication
Physiological Research, 2017, Vol 66, p673
- ISSN
0862-8408
- Publication type
Article
- DOI
10.33549/physiolres.933568