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- Title
Reporte de caso: primer caso de Síndrome de Guillain Barré pos-infección por SARS-COV-2 en Venezuela.
- Authors
Mujica, Andrea; Mujica, Endrina; Bello, Luis; Ospina, Diego; González-Inciarte, María Elena; Sumalave, Eudo; Arráiz, Nailet
- Abstract
SARS-CoV-2, responsible for the current pandemic, is a β-coronavirus that binds to ECA-2 receptors to infect the target cell. Fever, cough, and shortness of breath are the most common symptoms. Neurologic symptoms are gaining interest because of its association with pulmonary disease, direct Central Nervous System invasion by the virus, or post-infection onset. In this report, we describe a 52 years old male patient, with hypertension and diabetes mellitus type 2, presenting classic clinic of Guillain Barre Syndrome at the admission and respiratory symptoms 15 days before the appearance of neurologic symptoms. Antibody tests for SARS-CoV-2 were positives on two occasions and he reported the epidemiological continuous and direct nexus with people confirmed to be infected by SARS-CoV-2. Dysarthric language, dysphonia, facial diplegia, quadriparesis, and areflexia were finding at physical examination. The patient was transferred to ICU because of dyspnea but mechanical ventilation was not required and human immunoglobulin was administrated with significant improvement. A nasopharyngeal swab was taken at day 23 of the disease onset for RT-PCR, which resulted negative. We discuss the type and quality of specimen collection, phase of the disease when it is taken and the operator's expertise as determinants of the sensibility of this test. Despite this negative result, the clinical and epidemiological diagnosis of SARS-CoV-2 is clear. According to the literature review, this is the first Guillain Barre Syndrome post-infection by SARS-CoV-2 reported in Venezuela to the date.
- Publication
Gaceta Médica de Caracas, 2020, Vol 128, pS79
- ISSN
0367-4762
- Publication type
Article
- DOI
10.47307/GMC.2020.128.s1.9