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- Title
Nonuniform sliding-window reconstruction for accelerated dual contrast agent quantification with MR fingerprinting.
- Authors
Marriott, Anna; Rioux, James; Brewer, Kimberly
- Abstract
Objective: MR fingerprinting (MRF) can enable preclinical studies of cell tracking by quantifying multiple contrast agents simultaneously, but faster scan times are required for in vivo applications. Sliding window (SW)-MRF is one option for accelerating MRF, but standard implementations are not sufficient to preserve the accuracy of T2*, which is critical for tracking iron-labelled cells in vivo. Purpose: To develop a SW approach to MRF which preserves the T2* accuracy required for accelerated concentration mapping of iron-labelled cells on single-channel preclinical systems. Methods: A nonuniform SW was applied to the MRF sequence and dictionary. Segments of the sequence most sensitive to T2* were subject to a shorter window length, preserving the T2* sensitivity. Phantoms containing iron-labelled CD8+ T cells and gadolinium were used to compare 24× undersampled uniform and nonuniform SW-MRF parameter maps. Dual concentration maps were generated for both uniform and nonuniform MRF and compared. Results: Lin's concordance correlation coefficient, compared to gold standard parameter values, was much greater for nonuniform SW-MRF than for uniform SW-MRF. A Wilcoxon signed-rank test showed no significant difference between nonuniform SW-MRF and gold standards. Nonuniform SW-MRF outperformed the uniform SW-MRF concentration maps for all parameters, providing a balance between T2* sensitivity of short window lengths, and SNR of longer window lengths. Conclusions: Nonuniform SW-MRF improves the accuracy of matching compared to uniform SW-MRF, allowing higher accelerated concentration mapping for preclinical systems.
- Subjects
CONTRAST media; WILCOXON signed-rank test; IRON; GADOLINIUM; T cells
- Publication
MAGMA: Magnetic Resonance Materials in Physics, Biology & Medicine, 2024, Vol 37, Issue 2, p273
- ISSN
0968-5243
- Publication type
Article
- DOI
10.1007/s10334-023-01140-9