We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dual UV- and pH-Responsive Supramolecular Vesicles Mediated by Host-Guest Interactions for Drug Controlled Release.
- Authors
Zhang, Xiaojin; Zhuo, Renxi
- Abstract
To control the release of the drugs at specific time and location, dual UV- and pH-responsive supramolecular vesicles are described mediated by host-guest interactions. The hydrophobic segment β-CD-Azo-Ace (where β-CD, Azo, and Ace refer to β-cyclodextrin, azobenzene, and acetal, respectively) forms the inclusion with α-CD and the inclusion further self-assembles to form supramolecular vesicles in aqueous medium. The nanospherical supramolecular vesicles are ≈50 nm and high-efficiently load the drugs. Furthermore, supramolecular vesicles are dual UV- and pH-responsive, thus release the drugs at specific time (stimulated by UV) and location (stimulated by pH), which will have significant advantages for cancer treatment.
- Subjects
SUPRAMOLECULAR chemistry; HOST-guest chemistry; MOLECULAR self-assembly; CYCLODEXTRINS; HYDROPHOBIC compounds
- Publication
Macromolecular Chemistry & Physics, 2016, Vol 217, Issue 17, p1934
- ISSN
1022-1352
- Publication type
Article
- DOI
10.1002/macp.201600177